- Benefits of PPIs: Prilosec and other PPIs ease the discomfort of gastroesophageal reflux (GERD) and may reduce the risk of esophageal cancer in patients with Barrett’s esophagus, which is a serious complication of GERD.
- Potential harms from long-term use of PPIs: The downside of chronic use of PPIs include dementia ; stroke and heart attack ; kidney disease ; infections including pneumonia and C difficile diarrhea ; low magnesium and B 12 levels ; altered gut microorganisms ; stomach cancer ; and broken bones .
Carefully consider the risks from this group of medications when deciding whether to take them for more than a few weeks. Schedule a visit with your physician to discuss the risks and benefits as well as alternatives. For most GERD sufferers there are some fundamental lifestyle steps that can both reduce symptoms and risks – including risk of esophageal cancer – while minimizing medications: avoid sugars and starches; increase intake of high fiber foods such as vegetables; get daily exercise; eat probiotic foods such as fresh sauerkraut, kefir and yogurt; and reduce weight around the middle. Some traditional folk remedies can also be effective.
Miles Hassell MD